Characterization and optimization of the cell-electrode interface

James J. Hickman
Peter Molnar
Aman Behal
Vaibhav Thakore: Ph. D. student

The cell electrode interface can be optimized by modifying the electrode surface. The behavior of the interface can be modeled in appropriate details which makes the optimization possible.

Optimization of the cell-electrode interface in order to obtain high-quality extracellular action potential signals which enable the calculation of intracellular action potential shapes from the extracellular signal

Combined patch clamp recording and computer modeling of the extracellular and intracellular signals at different interface conditions.

We have developed a ‘data-true’ approach to modeling of the neuron-electrode junction by estimating a nonlinear dynamic model from the experimentally obtained input-output data records employing Volterra-Wiener characterization.

Parallel intracellular and extracellular recordings from NG108-15 cells

Reconstruction of an extracellular action potential based on the first and second order kernels obtained through white-noise analysis of the interface