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Effect of defined surfaces on cardiac myocyte physiology (NIH R21 EB002307-02) Peter Molnar: PI |
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| IDEA
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Biocompatibility / bioactivity could be determined independently of the bulk properties of the biomaterials using advanced surface modification methods and high-throughput in vitro physiological tests. | |
| GOAL |
Systematic study of the surface properties of the degradation products of the most commonly used cardiac scaffold materials (polylactic acid /PLA/ and polyglycolic acid /PGA/) |
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| APPROACH |
Surface modification with self-assembled monolayers and crosslinkers
Modification of surfaces with -OH and -COOH groups Physiological testing |
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| RESULTS |
Rat embryonic cardiac myocytes form smaller islands on hydroxyl surfaces
The number of beating islands are less on hydroxyl compared to carboxyl surfaces
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| WORK IN PROGRESS | Electrophysiological comparisons |
